Most coating processes typically utilize one of the general coating systems, such as the standard coating pan, perforated coating pan, and fluidized bed coater. A notable advancement in the efficacy of standard coating pan systems has been marked by the introduction of the Pelligrini pan, immersion sword, and immersion tube systems, where coating solutions are … Read more
Following are the critical parameters in Coating operation Gun Geometry and Calibration Gun geometry and Calibration refers to the position of spray guns which includes ‘Gun Calibration’, ‘Gun to bed distance’, ‘Gun to gun distance’, ‘Gun to side of pan’, ‘choked guns’ and ‘anti bearing technology’. Gun to bed distance: Gun to Bed Height: Gun … Read more
Cryopelletization is a technique in which droplets of a liquid formulation are transformed into solid spherical particles or pellets through the use of liquid nitrogen as the fixing medium. This technology, originally developed for the lyophilization of viscous bacterial suspensions, is capable of producing drug-loaded pellets in liquid nitrogen at -1600C. The process allows for … Read more
Melt Spheronization is a technique in which a drug substance along with excipients is transformed into a molten or semi-molten state, and then shaped using suitable equipment to create solid spheres or pellets. Initially, the drug substance is mixed with the relevant pharmaceutical excipients, including polymers and waxes, and then extruded at a specific pharmaceutical … Read more
Spray drying and Spray Congealing, also referred to as the globulation process, entail the atomization of hot melts, solutions, or suspensions to produce spherical particles or pellets. In both processes, the droplet size is maintained at a small scale to enhance the evaporation or congealing rate, resulting in the production of pellets that are typically … Read more
Spherical agglomeration, also known as balling, is a pelletization technique whereby powders are transformed into spherical particles through the addition of a suitable amount of liquid or exposure to elevated temperatures, facilitated by a continuous rolling or tumbling motion. Spherical agglomeration can be classified into two categories: Liquid induced agglomeration and Melt induced agglomeration. Liquid-induced … Read more
This method entails the application of successive layers of a solution and/or suspension containing drug substances and binders onto starter seeds, which can consist of inert materials or crystals of granules of the same drug. In this method, drug particles and other components are either dissolved or suspended in the application medium. The droplets strike … Read more
This method entails the application of successive layers of drug powder, along with excipients or both, onto pre-formed nuclei or cores using a binding liquid. During the powder layering process, the binding solution and finely milled powder are introduced simultaneously to a bed of starter seeds at a predetermined controlled rate. In the initial phases, … Read more
Pelletization is a process of agglomeration that transforms a fine powder mixture of drug(s) and excipients into small, free-flowing, spherical entities known as ‘pellets’. The method is essential for creating pellets that are uniform in size, possess a high drug loading capacity, and also mitigate segregation and dust. Rationale for Pelletization The controlled release application … Read more
Dr. Dale Wurster at the University of Wisconsin pioneered the Wurster process in the 1950s. In recent years, this process has gained traction within the Indian pharmaceutical industry due to the burgeoning opportunities in the generic market. Almost all leading companies are now exploring particle coating using the Wurster method. Furthermore, this process can be … Read more
