Mahummed Asif Pelletization is a process of agglomeration that transforms a fine powder mixture of drug(s) and excipients into small, free-flowing, spherical entities known as ‘pellets’. The method is essential for creating pellets that are uniform in size, possess a high drug loading capacity, and also mitigate segregation and dust. Rationale for Pelletization The controlled release application … Read more
Dr. Dale Wurster at the University of Wisconsin pioneered the Wurster process in the 1950s. In recent years, this process has gained traction within the Indian pharmaceutical industry due to the burgeoning opportunities in the generic market. Almost all leading companies are now exploring particle coating using the Wurster method. Furthermore, this process can be … Read more
A capsule is characterized as a solid dosage form that contains medicinal agents in the form of ‘powder’, ‘pellets’, ‘liquid pastes’, or ‘tablets’ enclosed within a hard or soft soluble shell. The shells are typically made from gelatine. Capsules are considered an oral drug delivery system that offers a dosage form that is nearly tasteless … Read more
Infrared spectroscopy (IR spectroscopy) refers to the branch of spectroscopy that focuses on the infrared portion of the electromagnetic spectrum, which consists of light characterized by longer wavelengths and lower frequencies than those of visible light. This field encompasses a variety of techniques, primarily centered around absorption spectroscopy. Capabilities of Infrared Analysis Applications of Infrared … Read more
The information provided above (including the procedure page) may give the impression that TLC is a relatively simple procedure. However, consider the experience of conducting a TLC for the first time, where one might observe spots scattered throughout and blurred, streaked areas. Like any technique, improvement comes with practice. Below are examples of typical issues … Read more
Thin layer chromatography (TLC) is a technique utilized in chromatography for the separation of mixtures. This process is conducted on a substrate made of glass, plastic, or aluminum foil, which is covered with a thin layer of adsorbent material, typically silica gel, aluminum oxide, or cellulose (blotter paper). The adsorbent layer is referred to as … Read more
What is a Material Safety Data Sheet, commonly referred to as MSDS? A material safety data sheet (MSDS) is a documented resource that supplies users and emergency responders with essential information and procedures for the safe handling and use of chemicals. MSDSs have existed in various forms since the era of the ancient Egyptians. While … Read more
Amorphous: A term that refers to a solid lacking a crystalline structure. Although there may be some local arrangement of atoms or molecules within an amorphous solid, there is an absence of long-range order. Examples include window glass and polystyrene. Atomic mass unit: An atomic mass unit, abbreviated as amu, is defined as one twelfth … Read more
The dissolution specification is defined by the amount (Q) of active substance that dissolves within a designated time frame, represented as a percentage of the content indicated on the product label. According to the Indian Pharmacopoeia, the dissolution specification is articulated in terms of the amount (D) of active substance that dissolves in a specified … Read more
According to the solubility and permeability of drugs, the following Biopharmaceutics Classification System (BCS) is suggested in the literature (Amidon 1995) This classification serves as a foundation for establishing in vitro dissolution specifications and also aids in predicting the probability of achieving a successful in vivo-in vitro correlation (IVIVC). The solubility of a drug is … Read more
