Equipment must be located, designed, constructed, adapted, and maintained to suit the operations to be carried out. The layout and design of equipment must aim to minimize the risk of errors and permit effective cleaning and maintenance in order to avoid cross-contamination, build-up of dust or dirt, and, in general, any adverse effect on the … Read more
GENERAL: SIFTING, MIXING ANG GRANULATION: COMPRESSION (TABLETS): COATING (TABLETS): FILLING OF HARD GELATIN CAPSULES: Empty Capsule shells shall be regarded as drug component and treated accordingly. They shall be stored under conditions which shall ensure their safety from the effects of excessive heat and moisture. PRINTING (TABLETS AND CAPSULES): PACKING OPERATION: Before packaging operations are … Read more
BLENDING PROCESS: Blending of solid particles refers to mixing of solids with the aim of attaining a uniform composition throughout the mix. In powder blending two or more dissimilar particulate solids are blended to give a random mix. Objective of blending is to form a homogeneous final product from two or more dissimilar raw materials. … Read more
Formulation of Capsules includes active ingredient and excipients (Fillers, Disintegrant and Glidant / Lubricant). Particle size distribution (PSD) and bulk density (BD/TD) of API/Excipients is important parameter in the selection of capsule size. Determination of appropriate capsule size for formulation: Blend with BD 0.4 g/cc and fill weight 200 mg to filled D= M/V 0.4 … Read more
CAPSULES: Capsules are solid dosage forms in which medicinal agents are enclosed within hard or soft soluble shell of gelatin. The capsules are regarded as container drug delivery system that provides a tasteless/odorless dosage form without need for secondary coating step. Advantages of Capsules: Disadvantages of Capsules: TYPES OF CAPSULES: Capsules can be broadly classified … Read more
Pharmaceutical Dosage Forms: Dosage forms are the means by which drug molecules are delivered to sites of action within the body. The requirement for dosage forms: Classification of pharmaceutical dosage forms: Dosage forms are classified according to route of administration and physical forms. ORAL DOSAGE FORMS: SOLID DOSAGE FORMS TABLET: A tablet is a hard, … Read more
