Cryopelletization is a technique in which droplets of a liquid formulation are transformed into solid spherical particles or pellets through the use of liquid nitrogen as the fixing medium. This technology, originally developed for the lyophilization of viscous bacterial suspensions, is capable of producing drug-loaded pellets in liquid nitrogen at -1600C. The process allows for … Read more
Melt Spheronization is a technique in which a drug substance along with excipients is transformed into a molten or semi-molten state, and then shaped using suitable equipment to create solid spheres or pellets. Initially, the drug substance is mixed with the relevant pharmaceutical excipients, including polymers and waxes, and then extruded at a specific pharmaceutical … Read more
Spray drying and Spray Congealing, also referred to as the globulation process, entail the atomization of hot melts, solutions, or suspensions to produce spherical particles or pellets. In both processes, the droplet size is maintained at a small scale to enhance the evaporation or congealing rate, resulting in the production of pellets that are typically … Read more
Spherical agglomeration, also known as balling, is a pelletization technique whereby powders are transformed into spherical particles through the addition of a suitable amount of liquid or exposure to elevated temperatures, facilitated by a continuous rolling or tumbling motion. Spherical agglomeration can be classified into two categories: Liquid induced agglomeration and Melt induced agglomeration. Liquid-induced … Read more
