BLENDING PROCESS: Blending of solid particles refers to mixing of solids with the aim of attaining a uniform composition throughout the mix. In powder blending two or more dissimilar particulate solids are blended to give a random mix. Objective of blending is to form a homogeneous final product from two or more dissimilar raw materials. … Read more
MILLING PROCESS: Milling process is also called as ‘screening’ and ‘sizing’ process. Milling is employed between RMG and Blending to crush the larger particles from granulation into uniform small particles which meets the process requirement. Milling isperformed to remove lumps, improve flow, reduce segregation and to control the particle size. Milling is performed by using … Read more
Granulation is required to improve the flow of powder mixtures and mechanical properties of Tablet. Granulation is the act or process in which primary powder particles are made to adhere to form larger, multiparticle entities called granules. It is the process of collecting particles together by creating bonds between them. Bonds are formed by compression … Read more
Unit Operations: The manufacture of Tablets is a complex multi-stage process under which the starting materials change their physical characteristics a number of times before the final dosage form is produced. Numerous unit operations are involved in making Tablets including sifting, mixing, granulation, drying, sizing, blending, lubrication, compression and coating. DISPENSING OF RAW MATERIALS (API … Read more
Formulation of Capsules includes active ingredient and excipients (Fillers, Disintegrant and Glidant / Lubricant). Particle size distribution (PSD) and bulk density (BD/TD) of API/Excipients is important parameter in the selection of capsule size. Determination of appropriate capsule size for formulation: Blend with BD 0.4 g/cc and fill weight 200 mg to filled D= M/V 0.4 … Read more
CAPSULES: Capsules are solid dosage forms in which medicinal agents are enclosed within hard or soft soluble shell of gelatin. The capsules are regarded as container drug delivery system that provides a tasteless/odorless dosage form without need for secondary coating step. Advantages of Capsules: Disadvantages of Capsules: TYPES OF CAPSULES: Capsules can be broadly classified … Read more
TABLETS: Tablets are the solid pharmaceutical dosage forms containing drug substances with or without suitable diluents and prepared either by compression or molding methods. Advantages of Tablets: Disadvantages of Tablets: EXCIPIENTS USED IN THE MANUFACTURE OF TABLETS: In addition to the active ingredient, solid dosage forms will also contain a range of substances called excipients. … Read more
Handling of Product quality complaints in pharmaceutical Industry: Product quality complaints are also known as Market complaints, customer complaints, Technical complaints, quality complaints, etc. What is complaint: A written or verbal communication received from Consumer, end-user, Client, Caregiver, Pharmacy, Regulatory authority, government agency, Qualified Person, Responsible Pharmacist, Retailer, Distributor, field staff, contract giver, beneficiary, purchaser … Read more
