Formulation of Capsules includes active ingredient and excipients (Fillers, Disintegrant and Glidant / Lubricant).
Particle size distribution (PSD) and bulk density (BD/TD) of API/Excipients is important parameter in the selection of capsule size.
Determination of appropriate capsule size for formulation:
Blend with BD 0.4 g/cc and fill weight 200 mg to filled
D= M/V 0.4 = 200 /v V = 0.5ml
Capsule Size = 1
