Cryopelletization is a technique in which droplets of a liquid formulation are transformed into solid spherical particles or pellets through the use of liquid nitrogen as the fixing medium. This technology, originally developed for the lyophilization of viscous bacterial suspensions, is capable of producing drug-loaded pellets in liquid nitrogen at -1600C. The process allows for … Read more
Melt Spheronization is a technique in which a drug substance along with excipients is transformed into a molten or semi-molten state, and then shaped using suitable equipment to create solid spheres or pellets. Initially, the drug substance is mixed with the relevant pharmaceutical excipients, including polymers and waxes, and then extruded at a specific pharmaceutical … Read more
This method entails the application of successive layers of a solution and/or suspension containing drug substances and binders onto starter seeds, which can consist of inert materials or crystals of granules of the same drug. In this method, drug particles and other components are either dissolved or suspended in the application medium. The droplets strike … Read more
This method entails the application of successive layers of drug powder, along with excipients or both, onto pre-formed nuclei or cores using a binding liquid. During the powder layering process, the binding solution and finely milled powder are introduced simultaneously to a bed of starter seeds at a predetermined controlled rate. In the initial phases, … Read more
Pelletization is a process of agglomeration that transforms a fine powder mixture of drug(s) and excipients into small, free-flowing, spherical entities known as ‘pellets’. The method is essential for creating pellets that are uniform in size, possess a high drug loading capacity, and also mitigate segregation and dust. Rationale for Pelletization The controlled release application … Read more
